MovDisordV3, Main, Exploration, bibRecord, 003239

Progressive supranuclear palsy: Phenotypic sex differences in a clinical cohort

Identifieur interne : 003239 ( Main/Exploration ); précédent : 003238; suivant : 003240

Progressive supranuclear palsy: Phenotypic sex differences in a clinical cohort

Auteurs : Yasuhiko Baba [États-Unis] ; John D. Putzke [États-Unis] ; Nathaniel R. Whaley [États-Unis] ; Zbigniew K. Wszolek [États-Unis] ; Ryan J. Uitti [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-05.

RBID : ISTEX:04F718B816E16C88F5CD37464FBDC60F1963A265

Descripteurs français

Pascal (Inist)
- Indice masse corporelle, Sexe, Système nerveux pathologie.

English descriptors

KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Body Mass Index, Body mass index, Cohort Studies, Female, Humans, Male, Middle Aged, Nervous system diseases, Phenotype, Retrospective Studies, Severity of Illness Index, Sex, Sex Characteristics, Supranuclear Palsy, Progressive (epidemiology), Supranuclear Palsy, Progressive (physiopathology), body mass index (BMI), clinical cohort, progressive supranuclear palsy (PSP), sex.
MESH :
- epidemiology : Supranuclear Palsy, Progressive.
- physiopathology : Supranuclear Palsy, Progressive.
- Adult, Age of Onset, Aged, Aged, 80 and over, Body Mass Index, Cohort Studies, Female, Humans, Male, Middle Aged, Phenotype, Retrospective Studies, Severity of Illness Index, Sex Characteristics.

Abstract

We examined sex‐based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, respectively) were similar. The overwhelming majority of sex‐based comparisons showed no significant difference on a variety of demographic, historical, and clinical characteristics, as well as measures of disease progression. The only differences observed were that men had significantly worse tremor as measured by the Unified Parkinson's Disease Rating Scale tremor subscore (0.9 for men and 0.3 for women, P < 0.01) and men had a significantly higher mean body mass index (BMI; 28.2 for men and 25.1 for women, P = 0.01), although these differences were not significant after Bonferroni correction. In general, the disease phenotype was similar between men and women, suggesting that sex may have little or no influence on the development, expression, or progression of the PSP phenotype. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/04F718B816E16C88F5CD37464FBDC60F1963A265/fulltext/pdf

DOI: 10.1002/mds.20769

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">We examined sex‐based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, respectively) were similar. The overwhelming majority of sex‐based comparisons showed no significant difference on a variety of demographic, historical, and clinical characteristics, as well as measures of disease progression. The only differences observed were that men had significantly worse tremor as measured by the Unified Parkinson's Disease Rating Scale tremor subscore (0.9 for men and 0.3 for women, P < 0.01) and men had a significantly higher mean body mass index (BMI; 28.2 for men and 25.1 for women, P = 0.01), although these differences were not significant after Bonferroni correction. In general, the disease phenotype was similar between men and women, suggesting that sex may have little or no influence on the development, expression, or progression of the PSP phenotype. © 2005 Movement Disorder Society</div>
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Movement Disorders (revue)

Progressive supranuclear palsy: Phenotypic sex differences in a clinical cohort

Progressive supranuclear palsy: Phenotypic sex differences in a clinical cohort

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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